(Tokyo Metropolitan University) Researchers from Tokyo Metropolitan University have successfully determined the high-resolution three-dimensional structure of proteins inside living eukaryotic cells. They combined 'in-cell' nuclear magnetic resonance (NMR) spectroscopy, a bioreactor system and cutting-edge computational algorithms to determine protein structures in crowded intracellular environments for the first time. The technique promises insight into the intracellular behavior of disease-causing proteins and novel drug screening applications, allowing in-situ visualization of how proteins respond to biochemical stimuli.
from EurekAlert! - Technology, Engineering and Computer Science http://bit.ly/2HPJ3Wm
Friday, May 31, 2019
In-situ measurement of 3D protein structure inside living eukaryotic cells
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